Blog Archives

GtoImmuPdb: technical update March 2017

The 4th alpha-release (v4.0) of the Guide to IMMUNOPHARMACOLOGY was released on 23rd March 2017. This blog post summarises some of the main features of the release and other developments as we moved toward our first public, beta-release in Spring

Tagged with: , ,
Posted in Guide to Immunopharmacology, Technical

Hot topics: Social network architecture of human immune cells unveiled by quantitative proteomics

The authors applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. The protein copy numbers revealed a specialization of immune cells for ligand and

Posted in Hot Topics

Hot topics: Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

Abstract: Cytokines are classically thought to stimulate downstream signaling pathways through monotonic activation of receptors. We describe a severe anemia resulting from a homozygous mutation (R150Q) in the cytokine erythropoietin (EPO). Surprisingly, the EPO R150Q mutant shows only a mild

Posted in Hot Topics

Hot topics: An atlas of human long non-coding RNAs with accurate 5′ ends

Using FANTOM5 cap analysis of gene expression (CAGE) data, the authors integrate multiple transcript collections to generate a comprehensive atlas of 27,919 human lncRNA genes with high-confidence 5′ ends and expression profiles across 1,829 samples from the major human primary

Posted in Hot Topics

Hot topics: The Ecstacy and Agony of Assay Interference Compounds

Editorial article in Biochemistry. [1] Alrich et al. (2017). Biochemistry 56(10):1363-1366. The Ecstacy and Agony of Assay Interference Compounds. [PMID: 28244742]

Posted in Hot Topics

Hot topics: Ligand and Target Discovery by Fragment-Based Screening in Human Cells

Description of a platform that marries fragment-based ligand discovery with quantitative chemical proteomics to map thousands of reversible small molecule-protein interactions directly in human cells, many of which can be site-specifically determined. [1] Parker et al. (2017).Cell. 168(3):527-541. Ligand and Target Discovery

Posted in Hot Topics

Database release 2017.2

Our 2nd database release of 2017 was published on 23rd March 2017. It now includes 15019 interactions between 2809 targets and 8832 ligands. For full release statistics see the About the Guide to PHARMACOLOGY page. Target updates The major part

Posted in Concise Guide to Pharmacology, Database updates, Technical