Blog Archives

Hot topics: Intracellular allosteric antagonism of the CCR9 receptor

Chemokines and their GPCR receptors are important drug targets in a broad range of diseases due to their role in immune defence (by controlling migration, activation and survival of immune cells), viral entry, tumour growth and metastasis. This article presents

Posted in Hot Topics

Hot topics: Visualizing GPCR ‘Megaplexes’ Which Enable Sustained Intracellular Signaling

Spotlight article [1] discussing the range of cutting-edge techniques that have been employed to visualize ‘megaplexes’ consisting of a G protein-coupled receptor (GPCR) bound to ╬▓-arrestin in intracellular endosomes following agonist-induced internalization. Surprisingly, the complex includes simultaneous binding of the

Posted in Hot Topics

Hot topics: Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

A report on the structures of type 2 ryanodine receptor from porcine heart at near-atomic resolution [1]. Structural and mutational characterisations provide important insights into the gating and disease mechanisms of RyR2. Guide to Pharmacology: Ryanodine receptor family. [1] Peng et

Posted in Hot Topics

GtoImmuPdb: technical update February 2017

The 3rd alpha-release (v3.0) of the Guide to IMMUNOPHARMACOLOGY was released on 30th January 2017. This blog post summarises some of the main features of the release and other developments as we moved toward our first public, beta-release in Spring

Posted in Guide to Immunopharmacology, Technical

Reference Citations in BJP and NAR metrics

Introduction Like other database resources, we collate measures of impact for various uses. These include our own internal bi-annual IUPHAR/GtoPdb review meetings, documenting outputs of past grants and applications for new ones. While there is a widening choice of these

Posted in Publications, Uncategorized

Database release 2017.1

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We are pleased to announce our first database release of 2017 on 26th Jan 2017. While there are no major updates in this release, it includes several bug fixes and new ligands of relevance to immunopharmacology. Our new portal, the

Posted in Database updates, Technical

IUPHAR review 100 in Pharm Revs and review 21 in BJP

NC-IUPHAR has just published its 100th review in Pharmacological Reviews

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Posted in Publications