Blog Archives

Accessing WHO Essential Medicines in GtoPdb

The Guide to Pharmacology (GtoPdb) currently contains data on over 10,000 different ligands which are categorised into an number of different groups or classifications. The ligand list page (https://www.guidetopharmacology.org/GRAC/LigandListForward?type=WHO-essential&database=all) provides a directory of all the ligands described in the database,

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Posted in Technical, Tutorials and Guides

Database Release 2020.3

The latest release of the Guide to PHARMACOLOGY database, version 2020.3, has now been made. A large focus of our curation over the last couple of month since our 2020.2 release We are pleased to have been able to make

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Posted in Database updates, Technical

Database Release 2020.2

We are pleased to have been able to make an expeditious database release (version 2020.2), following on from our last update in March 2020 in order to make public new curation specifically related to SARS-CoV-2. Content Updates GtoPdb now includes

Posted in Database updates, Technical

Database Release 2020.1

We are pleased to announce our first database release of 2020 – version 2020.1. Coronavirus (Covid-19) We have added a new coronavirus page to the Guide to Pharmacology which aims to consolidate key pharmacological information and resources related to coronavirus.

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Posted in Database updates, Technical

Database Release 2019.5

Our fifth and final database release of 2019 has been made and includes a number of minor content and website updates. Crucially, it comes at a time when we have just published our most recent database update in Nucleic Acids

Posted in Database updates, Technical

Database Release 2019.4

We are very pleased to announce our a new release of the IUPHAR/BPS Guide to Pharmacology. This version (2019.4) is the fourth this year and includes the first full-release of the IUPHAR/MMV Guide to Malaria Pharmacology. Content Updates GtoPdb now

Posted in Database updates, Guide to Immunopharmacology, Guide to Malaria Pharmacology, Technical

Database Release 2019.3

We have now made the third IUPHAR/BPS Guide to Pharmacology database release of 2019 (2019.3). It includes updates focussed on preparation for the next edition of The Concise Guide to PHARMACOLOGY (2019/20), due out later this year. Content Updates GtoPdb

Posted in Database updates, Guide to Malaria Pharmacology, Hot Topics, Technical

Guide to MALARIA PHARMACOLOGY: introducing a new resource

We are pleased to make public the first beta-release (v1.0) of the Guide to MALARIA PHARMACOLOGY (GtoMPdb), a new extension to the existing Guide to PHARMACOLOGY (GtoPdb). The GtoMPdb is being developed as a joint initiative between Medicines for Malaria

Posted in Guide to Malaria Pharmacology, Technical

GtoPdb: Database Status Reports

As some of our contacts may know, we hold hemi-annual meetings between IUPHAR, BPS the GtoPdb team, together with invited guests from our collaborators and NC-IUPHAR committee representatives. Covering ~ 2.5 days these usually take place in Paris or Edinburgh.

Posted in Database updates, Technical, Uncategorized

GtoImmuPdb: technical update March 2018 – beta-release v3

We are pleased to announce the third, beta-release of the Wellcome Trust-funded IUPHAR Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb). Since our last release in August 2017 we have implemented developments that include disease summary pages, graphical browsing features and extensions and improvements

Posted in Guide to Immunopharmacology, Technical

Database release 2018.1

Pharmacology Search results table

The first GtoPdb and GtoImmuPdb beta release of  2018 includes plenty of target and ligand updates as well as announcing some important new features. As always, full content statistics for release 2018.1 can be found on the database about page.

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Posted in Database updates, Technical

Database release 2017.6

The sixth and final IUPHAR/BPS Guide to PHARMACOLOGY release of 2017 has been published on 29th November. This release includes new content for the Guide to IMMUNOPHARMACOLOGY, which is currently still in beta phase. This release includes the following updates

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Posted in Database updates, Guide to Immunopharmacology, Technical

GtoImmuPdb: technical update November 2017

This blog-post will discuss the major developments planned for the Guide to IMMUNOPHARMACOLOGY as we look ahead to our next beta-release (v3.0) in early 2018. This month, the updated IUPHAR/BPS Guide to PHARMACOLOGY NAR Database Issue has been published online

Posted in Guide to Immunopharmacology, Technical

New source cross-references in release 2017.5

(minor updates 15 Sep 2017) The statistics of content are presented as usual in the release notes and The Guide to IMMUNOPHARMACOLOGY has a separate update.  This post describes changes and updates to other resources we provide links to, that

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Posted in Database updates, Technical

Database release 2017.5

The 5th IUPHAR/BPS Guide to PHARMACOLOGY database release of 2017 includes updates to several target families, and new targets and ligands added, focusing on those relevant to immunopharmacology. We also announce a new organisation for ligand families and groups. This

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Posted in Database updates, Technical

Guide to IMMUNOPHARMACOLOGY – beta release v2.0, August 2017

We are please to announce the second, beta-release of the Wellcome Trust-funded IUPHAR Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb). Since our first beta-release back in May 2016, we have undertaken a user-testing exercise to gather feedback on the layout, navigation and content

Posted in Guide to Immunopharmacology, Technical

HGNC gene links to GtoPdb

As regular users of GtoPdb will be aware, our target pages include HUGO Gene Nomenclature Committee (HGNC) gene symbols, nomenclature and links to HGNC gene pages (Fig 1). HGNC pages in turn link back to GtoPdb target pages under the

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Posted in Technical

Database release 2017.4

Our 4th database release of 2017 was published on 23rd May 2017. It now includes 15133 interactions between 2813 targets and 8900 ligands. For full release statistics see the Guide to PHARMACOLOGY About page. Target Updates Updates have been made to

Posted in Database updates, Guide to Immunopharmacology, Technical

GtoImmuPdb: technical update March 2017

The 4th alpha-release (v4.0) of the Guide to IMMUNOPHARMACOLOGY was released on 23rd March 2017. This blog post summarises some of the main features of the release and other developments as we moved toward our first public, beta-release in Spring

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Posted in Guide to Immunopharmacology, Technical

Database release 2017.2

Our 2nd database release of 2017 was published on 23rd March 2017. It now includes 15019 interactions between 2809 targets and 8832 ligands. For full release statistics see the About the Guide to PHARMACOLOGY page. Target updates The major part

Posted in Concise Guide to Pharmacology, Database updates, Technical

GtoImmuPdb: technical update February 2017

The 3rd alpha-release (v3.0) of the Guide to IMMUNOPHARMACOLOGY was released on 30th January 2017. This blog post summarises some of the main features of the release and other developments as we moved toward our first public, beta-release in Spring

Posted in Guide to Immunopharmacology, Technical

Database release 2017.1

We are pleased to announce our first database release of 2017 on 26th Jan 2017. While there are no major updates in this release, it includes several bug fixes and new ligands of relevance to immunopharmacology. Our new portal, the

Posted in Database updates, Technical

GtoImmuPdb: technical update December 2016

Our final technical update for 2016 covers our v2.0 alpha-release, presentation at Pharmacology 2016 and future plans.

Posted in Guide to Immunopharmacology, Technical

GtoImmuPdb: technical update November 2016

During October we have made the first alpha-release (v1.0) of the Guide to IMMUNOPHARMACOLOGY. This blog post summarises some of the main features of the release and work on the documentation. This first release marks an important step towards the

Posted in Technical

SynPharm: A New Annexe to the Guide to PHARMACOLOGY

We have created a new sister database to the main Guide to PHARMACOLOGY (GtoPdb) – SynPharm, a database of drug-responsive protein sequences. Each sequence in SynPharm is derived from a GtoPdb interaction. In each case we have identified the continuous

Posted in Technical

GtoImmuPdb: technical update September 2016

The focus of development in the last month has been on preparing the GtoImmuPdb portal for alpha-release and building landing-pages for process and cell type association lists.

Posted in Guide to Immunopharmacology, Technical

GtoImmuPdb: technical update August 2016

The major developmental extension to GtoImmuPdb has been incorporation of cell type associations and web-app development to display both process and cell type data.

Posted in Guide to Immunopharmacology, Technical

GtoImmuPdb: technical update May 2016

Development of the Guide to Immunopharmacology (GtoImmuPdb) continues and this is an update of progress since our last update in February 2016. Since then, the GtoImmuPdb April Meeting was held in Edinburgh, where a detailed update on the status of

Posted in Guide to Immunopharmacology, Technical

GtoImmuPdb: technical update Feb 2016

Technical update from database and curation team behind The Guide to Immunopharmacology

Posted in Guide to Immunopharmacology, Technical

Database Release August 2015

The first version of our REST web services is now available for beta testing

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Posted in Database updates, Technical

MySQL relational database and other options for download

As mentioned in various places (including our FAQ) we welcome the downloading of our content in various slices and formats (listed here). Please contact us if you do this, not only out of professional courtesy but also so we can

Posted in Technical

Retrospective entity linking from the literature: IUPHAR allostery review

Many of you will have noticed a gradual blurring of the distinction between publications and databases. One manifestation of this is “live linking” where entities within the text of an open access manuscript connect directly to the URL of an

Posted in Technical

A Pharmacologists’ Guide to Resolving Chemical Structures and their Protein Targets from the Literature

This is an introduction to resolving bioactive ligands and their protein targets from the literature. It includes their conversion to standardised molecular identifiers so these can be communicated  to the Guide to PHARMACOLOGY (GtoPdb) team. (n.b. identifying what is already

Posted in Chemical curation, Drug targets, Technical

Chemical search drawing tools: updating Java and security exceptions

Regular users of the Guide to PHARMACOLOGY will be aware that the site includes a ‘Chemical structure search’ function whereby users can draw chemical structures or parts of structures and use these to search against the database. Users can also

Posted in Technical