We are pleased to announce the latest release of the Guide to PHARMACOLOGY database, version 2020.5. This is the last planned release for 2020.
The 2020.5 release contains:
- 1,567 human targets with curated quantitative ligand interactions.
- 10,659 ligands, 7,884 of which have curated quantitative target interactions.
- 1,614 approved drugs, 974 with curated quantitative interactions.
- Clinical use summaries for over 2,800 ligands.
Coronavirus
The Guide to Pharmacology coronavirus information page continues to be updated on a regular basis to capture the latest pharmacological strategies under investigation to mitigate against COVID-19.
We have curated some of the entities from the WHO list of COVID-related therapeutics that was released at the end of October: alunacedase alfa, eclitasertib, enpatoran, molnupiravir, nezulcitinib, subasumstat.
Curation Updates
There have been updates to the S1P and LPA receptor families, the bradykinin receptors family, and the S1P turnover enzymes. The P-type ATPases have been expanded and reorganised.
A new family of transporters has been added, SLC66 Lysosomal amino acid transporters, and cyclic GMP-AMP synthase (cGAS) has been added as a new immunopharmacology target.
Website Updates
- We have started taking step to identify and and fix high-priority accessibility problems
- Links to AntibioticDB now cover over 280 ligands.
Guide to Malaria Pharmacology (GtoMPdb)
These are the recent advancements made in the GtoMPdb for this database release:
- The Antimalarial targets family and the Antimalarial ligands family have been updated, giving a total of 33 P. falciparum (3D7) targets and 100 ligands tagged as antimalarial in the database.
guidetopharmacology blog 
[…] our 2020.5 update we have added 220 new ligands. These have all been manually curated with chemical or peptide […]