Blog Archives

Hot topic: Pharmacogenomics of GPCR Drug Targets

A system of rigorous clinical trials and regulation exist to ensure that a new drug is safe and effective when reaching the market. However, natural human genetic variation(s) may cause individuals to respond differently to the same medication. A collaboration

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Posted in Drug targets, Hot Topics

Proteases in the latest GtoPdb release

The team have surfaced more fruits of our labour in release  2014.3 of GtoPdb (this is now our official acronym for the database).   This post will highlight protease expansion during this curation cycle (see page 10 in our newsletter for an introduction to our

Posted in Drug targets

A Pharmacologists’ Guide to Resolving Chemical Structures and their Protein Targets from the Literature

This is an introduction to resolving bioactive ligands and their protein targets from the literature. It includes their conversion to standardised molecular identifiers so these can be communicated  to the Guide to PHARMACOLOGY (GtoPdb) team. (n.b. identifying what is already

Posted in Chemical curation, Drug targets, Technical

New content and features on The Guide to PHARMACOLOGY: our April 2014 update

Last month we updated our site to include the results of our curation efforts since the start of the year. Our main focus of 2014 so far has been curation of approved drugs and clinical targets, and the site has

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Posted in Database updates, Drug targets

Drug and target lists on the Guide to PHARMACOLOGY

Given the intense interest in drugs and their human targets, both in pharmacology and chemical biology, obtaining a simple list of either is surprisingly difficult. There are many reasons for this. One of them is that those lists that can

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Posted in Drug targets