Version 2025.4 of the IUPHAR/BPS Guide to Pharmacology database was released on 10th December 2025, our fourth and final release of the year. This blog post gives details of the key content updates and website changes. GtoPdb now contains: 3,118…
Blog Archives
Database Release 2025.3
Version 2025.3 of the IUPHAR/BPS Guide to Pharmacology database was released on 10th September 2025, our second release of the year. This blog post gives details of the key content updates and website changes. GtoPdb now contains: 3,112 human targets,…
Commercial Access Fees for GtoPdb
Why is IUPHAR/BPS Guide to Pharmacology asking for access fees? The IUPHAR/BPS Guide to Pharmacology (GtoPdb) has always been an open-access, freely available resource. Our expert-curated database of pharmacological data has been maintained over the past 10-15 years on ever…
Posted in Uncategorized
Database Release 2025.2
Version 2025.2 of the IUPHAR/BPS Guide to Pharmacology database was released on 18th June 2025, our second release of the year. This blog post gives details of the key content updates and website changes. GtoPdb now contains: 3,103 human targets,…
Using LLMs for Text-to-SQL generation on the Guide to Pharmacology
In the last academic year (September 24 – April 25) we supported two undergraduate, final-year projects (Honours Projects) that looked into uses of ‘artificial intelligence’ tools to improve access to or capabilities of the Guide to Pharmacology. Both projects focussed…
Posted in Guide to Immunopharmacology, Uncategorized
GtoPdb Database Report – April 2025 now available
Our latest database report provides an overview of progress and status of the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) for the period November 2024 to April 2025. Click to access GtoPdb_Database_Report_Apr_2025.pdf It can also be access at our Zenodo repository https://doi.org/10.5281/zenodo.15342610
Database Release 2025.1
The latest release (version 2025.1) of the IUPHAR/BPS Guide to Pharmacology database has been made. Released on 2nd April 2025 this is the first release of the year. The following blog post gives details of the key content updates and…
Database Release 2024.4
The latest release (version 2024.4) of the IUPHAR/BPS Guide to Pharmacology database has been made. Released on 4th December 2024 this is the fourth release of the year. The following blog post gives details of the key content updates and…
GtoPdb Database Report – Nov 2024 now available
Our latest database report provides an overview of progress and status of the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) for the period April 2024 to October 2024. Click to access GtoPdb_Database_Report_Nov_2024.pdf It can also be access at our Zenodo repository https://doi.org/10.5281/zenodo.14046004…
Posted in Database updates, Publications
Database Release 2024.3
The latest release (version 2024.3) of the IUPHAR/BPS Guide to Pharmacology database has been made. Released on 3rd October 2024 this is the third release of the year. The following blog post gives details of the key content updates and…
Database Release 2024.2
The latest release (version 2024.2) of the IUPHAR/BPS Guide to Pharmacology database has been made. Released on 26th June 2024 this is the second release of the year. The following blog post gives details of the key content updates and…
Database Release 2024.1
A new release, version 2024.1, has been made of the IUPHAR/BPS Guide to Pharmacology database. Released on 26th March 2024 this is the first release of the year. The following blog post gives details of the key content updates and…
BJP Concise Guide to Pharmacology 2023/24 – out now!
The essential guide for those working in the vital search for new drugs A FREE education and research resource What’s in it for you? Published as a special issue in the British journal of Pharmacology every 2 years, The Concise Guide…
GtoPdb is a Global Core Biodata Resource
The IUPHAR/BPS Guide to Pharmacology is delighted to be named as one of 15 new Global Core Biodata Resources (GCBRs) by the Global Biodata Coalition (GBC). The GBC announced the outcome of its 2023 selection round for GCBRs on 11th…
Posted in Hot Topics, Uncategorized
Database Release 2023.3
The latest release of the IUPHAR/BPS Guide to Pharmacology database was made on 29th November 2023. This database release is version 2023.3, and is the third release this year. The following blog post gives details of the key content updates…
Database Release 2023.2
The latest release of the IUPHAR/BPS Guide to Pharmacology database was made on 7th August 2023. This database release is version 2023.2, and is the second release this year. The following blog post gives details of the key content updates…
Database Release 2023.1
The latest release of the IUPHAR/BPS Guide to Pharmacology database was made on 26th April 2023. This database release is version 2023.1, and is the first release this year. The following blog post gives details of the key content updates…
New Cymdeithas Ddysgedig Cymru / Learned Society of Wales Fellows
We wish to offer our congratulations to Professor Jamie Davies, Professor of Experimental Anatomy, University of Edinburgh, who has been elected to the Cymdeithas Ddysgedig Cymru/Learned Society of Wales. The society’s new Fellows include academics from across Welsh and UK…
Posted in Guide to Immunopharmacology, Uncategorized
Exploiting the Guide to Pharmacology substance (SID) tags in PubChem
This post on SID tagging has been reproduced, with permission, from Dr. Chris Southan’s original post in his blog – Bio <-> Chem. It is intended to be user-orientated, those interested in the technicalities are welcome to contact the Guide…
Database Release 2022.4
The latest release of the IUPHAR/BPS Guide to Pharmacology database was made on 13th December 2022. This database release is version 2022.4, and is the fourth release this year. GtoPdb now contains: 3,013 human targets, 1,633 of which have curated…
Hot Topics: FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2 This manuscript (1) reports on extensive and compelling experimental evidence and translational data from retrospective review of clinical registries, which show that pharmacological inhibition of the farnesoid X receptor (FXR)…
Database Release 2022.3
The latest release of the IUPHAR/BPS Guide to Pharmacology database was made on 13th October 2022. This database release is version 2022.3, and is the third release this year. The following blog post gives details of the key content updates…
Database Release 2022.2
A new database release (version 2022.2) of the IUPHAR/BPS Guide to Pharmacology was made on 9th June 2022. This blog post gives details of the key content updates and website changes. GtoPdb now contains: 3,002 human targets, 1,611 of which…
Prof. Jamie Davies – RSE Fellow
Congratulations to Professor Jamie Davies, Professor of Experimental Anatomy, University of Edinburgh, who has been elected to a Fellowship by The Royal Society of Edinburgh, Scotland’s National Academy. Fellowships are awarded to individuals in academia, business and public service who…
Hot Topics: A new study shows that human ageing is absolutely precise, when disease is eliminated, and accompanied by a disintegration of metabolic efficiency
Human ageing is just disintegration, but absolutely precise, linked to loss of VO2 max, which is why COVID is age-related. A new study (1) shows that the decline in human performance with age at 5000 m, an athletic event requiring…
Hot Topics: Endothelin-1 pathway, a new therapeutic target for COVID-19
SARS-CoV-2 gains entry into the body mainly via the lungs. After entering the blood, the virus rapidly multiplies to infect nearby cells. Endothelial cells line every blood vessel and have a surface area similar to a tennis court. These cells…
Database Release 2022.1
We are pleased to announce that the first IUPHAR/BPS Guide to Pharmacology of 2022 was made on 31st March 2022. database. This release is version 2022.1 and this blog post gives details of the key content updates and website changes.…
Hot Topics: SARS-CoV-2 and the truncated ACE-2 variant
ACE2 (Guide to Pharmacology Target id: 1614) normally functions as an enzyme metabolising peptides that regulate the cardiovascular system. As is well known though, it has recently gained additional scientific fame by also acting as a receptor for SARS-CoV-2. This study [1] compared…
Database Release 2021.4
The 2021.4 release of the IUPHAR Guide to Pharmacology was made on 14th December 2021. This blog post gives details of the key content updates and website change The 2021.4 release contains: 3,000 human targets with curated quantitative ligand interactions.…
Posted in Database updates, Guide to Malaria Pharmacology
Hidden REF award to Guide to Pharmacology
It is with great pleasure that we can announce that the IUPHAR/BPS Guide to PHARMACOLOGY has been given a hidden REF award in the category ‘applications of research’. The hidden Ref (https://hidden-ref.org) is a national ‘competition’, supported by publishers, learned…
Database Release 2021.3
Database release details for the first release in 2021 of the Guide to PHARMACOLOGY database, version 2021.1
Hot Topics: Trends in kinase drug discovery: twenty years of successfully targeting the kinome
The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology area and beyond. Continued advances in the molecular understanding of…
Database Release 2021.2
Database release details for the first release in 2021 of the Guide to PHARMACOLOGY database, version 2021.1
Database Release 2021.1
Database release details for the first release in 2021 of the Guide to PHARMACOLOGY database, version 2021.1
GtoPdb pre-release ligands (2021.1)
These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2021.1). Ligand ID: 11395Names: MK-7110Comment: MK-7110 (originally OncoImmune’s CD24Fc) is a synthetic…
Hot Topics: Gene Symbol usage and the need to do better
The GtoPdb team need no convincing about the importance of eliminating equivocality in gene and gene product names, as they are used in the pharmacology, chemical biology and drug discovery literature. Crucially, this also applies to their inclusion in curated…
Posted in Hot Topics
GtoPdb at Pharmacology 2020
The BPS Pharmacology 2020 Meeting is being held virtually this year, but this hasn’t diminished Guide to Pharmacology presence. On Monday 14th, Dr. Simon Harding presented our poster on ‘Expansion for anti-malarial, antibiotics and COVID-19’. Click to view poster. On…
Database Release 2020.5
We are pleased to announce the latest release of the Guide to PHARMACOLOGY database, version 2020.5. This is the last planned release for 2020. The 2020.5 release contains: 1,567 human targets with curated quantitative ligand interactions. 10,659 ligands, 7,884 of…
Database Release 2020.4
The latest release of the Guide to PHARMACOLOGY database, version 2020.4, has now been made. Coronavirus The Guide to Pharmacology coronavirus information page continues to be updated on a regular basis to capture the latest pharmacological strategies under investigation to mitigate against…
Tagged with: 2020.4, database release, oncology targets, WHO essential medicines
Posted in Database updates
Posted in Database updates
Hot Topics: Soluble ligands as drug targets
Historically, the main classes of drug targets have been receptors, enzymes, ion channels and transporters which are primarily targeted by small molecules. However, advances in molecular biology, genomics, and pharmacology have facilitated the development of different therapeutic modalities which in…
GtoPdb pre-release ligands (2020.4)
These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2020.4). Ligand ID: 11132 Name: otilimab Comment: Otilimab (MOR103, GSK3196165) is a…
Hot Topics: TMEM163 regulates ATP-gated P2X receptor and behaviour
It is now clear that ligand-gated ion channels (LGICs) are not “stand alone” functional units, but form complexes with other components, including scaffolding proteins, regulatory proteins and enzymes. Besides their important physiological roles, these modulating proteins are also potential targets…
Accessing WHO Essential Medicines in GtoPdb
The Guide to Pharmacology (GtoPdb) currently contains data on over 10,000 different ligands which are categorised into an number of different groups or classifications. The ligand list page (https://www.guidetopharmacology.org/GRAC/LigandListForward?type=WHO-essential&database=all) provides a directory of all the ligands described in the database,…
Database Release 2020.3
The latest release of the Guide to PHARMACOLOGY database, version 2020.3, has now been made. A large focus of our curation over the last couple of month since our 2020.2 release We are pleased to have been able to make…
Hot Topics: A trio of GPCR peptide publications
This post covers three recent publications with a common theme and whose authors are collaborators with GtoPdb, thus making them as a trio particularly suitable for combined review. These are; Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled…
GtoPdb pre-release ligands (2020.3)
These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2020.3). Ligand ID: 10891 Name: aviptadil Comment: Aviptadil is a vasoactive intestinal…
Database Release 2020.2
We are pleased to have been able to make an expeditious database release (version 2020.2), following on from our last update in March 2020 in order to make public new curation specifically related to SARS-CoV-2. Content Updates GtoPdb now includes…
Posted in Database updates, Technical
GtoPdb pre-release ligands (2020.2)
These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2020.2 – no earlier than April 2020). Ligand ID: 10716 Name: PRD_002214…
Database Release 2020.1
We are pleased to announce our first database release of 2020 – version 2020.1. Coronavirus (Covid-19) We have added a new coronavirus page to the Guide to Pharmacology which aims to consolidate key pharmacological information and resources related to coronavirus.…
Hot Topics: Virtual screening on the crystal structure of the G protein-coupled melatonin MT1 receptor reveals several new chemical scaffolds with biological activity
Melatonin targets two high-affinity receptors, MT1 and MT2, that belong to the G protein-coupled receptor (GPCR) superfamily (1,2). Drugs acting on melatonin receptors are subscribed for circadian disorders (jet lag, shift work, etc.), insomnia and major depression (3). All marketed…
guidetopharmacology blog 