Why is IUPHAR/BPS Guide to Pharmacology asking for access fees? The IUPHAR/BPS Guide to Pharmacology (GtoPdb) has always been an open-access, freely available resource. Our expert-curated database of pharmacological data has been maintained over the past 10-15 years on ever…
Blog Archives
Using LLMs for Text-to-SQL generation on the Guide to Pharmacology
In the last academic year (September 24 – April 25) we supported two undergraduate, final-year projects (Honours Projects) that looked into uses of ‘artificial intelligence’ tools to improve access to or capabilities of the Guide to Pharmacology. Both projects focussed…
Posted in Guide to Immunopharmacology, Uncategorized
GtoPdb is a Global Core Biodata Resource
The IUPHAR/BPS Guide to Pharmacology is delighted to be named as one of 15 new Global Core Biodata Resources (GCBRs) by the Global Biodata Coalition (GBC). The GBC announced the outcome of its 2023 selection round for GCBRs on 11th…
Posted in Hot Topics, Uncategorized
New Cymdeithas Ddysgedig Cymru / Learned Society of Wales Fellows
We wish to offer our congratulations to Professor Jamie Davies, Professor of Experimental Anatomy, University of Edinburgh, who has been elected to the Cymdeithas Ddysgedig Cymru/Learned Society of Wales. The society’s new Fellows include academics from across Welsh and UK…
Posted in Guide to Immunopharmacology, Uncategorized
Hidden REF award to Guide to Pharmacology
It is with great pleasure that we can announce that the IUPHAR/BPS Guide to PHARMACOLOGY has been given a hidden REF award in the category ‘applications of research’. The hidden Ref (https://hidden-ref.org) is a national ‘competition’, supported by publishers, learned…
GtoPdb pre-release ligands (2021.1)
These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2021.1). Ligand ID: 11395Names: MK-7110Comment: MK-7110 (originally OncoImmune’s CD24Fc) is a synthetic…
Hot Topics: Rise up against statistical significance, probably.
A recent commentary in Nature has the provocative title “Retire Statistical Significance” (1, with a list of more than 800 signatories) and has been widely interpreted as a call for the entire concept of statistical significance to be abandoned. Closer…
Commentary on the distinction between Cannabis and cannabinoids
The Cannabis plant is a natural product from which more than 100 apparently unique metabolites (cannabinoids) have been identified. Many of these have been found in human plasma following consumption of Cannabis preparations. The most well-recognised is tetrahydrocannabinol, THC, because…
Posted in Hot Topics, Uncategorized
GtoPdb: Database Status Reports
As some of our contacts may know, we hold hemi-annual meetings between IUPHAR, BPS the GtoPdb team, together with invited guests from our collaborators and NC-IUPHAR committee representatives. Covering ~ 2.5 days these usually take place in Paris or Edinburgh.…
PubMed Commons and Altmetrics
This has been split from an updated older post on Citation profiles for our NAR and Concise Guide papers and this section will be updated soon PubMed Commons In addition to keeping an eye on citations per se we also…
Posted in Uncategorized
Impact statements and content subsumation: BPS 2017 follow-up
We were pleased to catch up with many GtoPdb/GtoImmuPdb users, aficionados, friends and affiliates at the BPS Pharmacology 2017 in the QEII Center in London. You can find our presentations and posters on Slideshare. Associated with this presence we have…
Posted in Uncategorized
Anti-infective pilot entries
GtoPdb has been traditionally focused on the pharmacology associated with human diseases (i.e. we have not been funded to cover anti-infectives). In 2017 we have been exploring possible funding opportunities to extend into expert curation of anti-infectives, particularly in the…
Posted in Uncategorized
GtoPdb Ligands in PubChem
GtoPdb and its precursor IUPHAR-DB have been capturing the structures of pharmacologically relevant ligands since 2005. The fig.1. snapshot below shows the approved drug section of our eight-category ligand classification As an active collaboration with the PubChem team, we have…
Posted in Uncategorized
Why Data Citation Is a Computational Problem
By Peter Buneman The database development team encouraged me to write this off-topic blog on data citation, as it may be of interest to people involved with the IUPHAR/BPS Guide to Pharmacology (GtoPdb). It must be almost ten years ago…
Posted in Uncategorized
Recent DrugBank Changes
The DrugBank database has just announced (09 May 2016) more restrictive access conditions including user registration. Not unexpectedly, this has prompted discussion on Twitter and elsewhere (e.g. ThinkLab. including some from the DrugBank team). We enjoy long-standing contacts with the…
Posted in Uncategorized
Assessment of GtoPdb in-links
A valuable aspect of biological databases in general and the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) in particular, are out-links to and in-links from, other relevant resources.
Curating PDB links between proteins and 3D chemical structures
We know users find our curated PDB links of high value, particularly where the ligand co-crystalised within the target protein is an activity-mapped approved drug, clinical candidate or key metabolite. The comparative SAR insights these can provide are substantial, especially…
Posted in Uncategorized
The drug class of 2014
Around this time of year there is much interest and comment from the pundits concerning the previous year’s drug approvals. Team member Chris Southan has a history of picking out aspects of the PubChem entries on his own blog and…
Posted in Uncategorized
Our upcoming release
As we approach our 2014.3 release in a few weeks time the curation team are busy adding and updating records. This includes a round of inputs an revisions from our protein family committees and a new FAQ. Just to remind…
Posted in Uncategorized
NC-IUPHAR newsletter Summer 2014
The latest edition of our newsletter can be read at the link below: NC-IUPHAR_Newsletter_Summer_2014 Special features covered in this issue include: A detailed profile of the PubChem database contributed by their lead scientist Evan Bolton, with whom we have worked…
Posted in Uncategorized
BPS awards JR Vane Medal to Professor Tony Harmar
The British Pharmacological Society today announced the winners of several of their 2014 awards and prizes. Among these awards is the JR Vane Medal which has been awarded posthumously to Professor Tony Harmar. This award reflects the tremendous contribution Tony…
Posted in Uncategorized
guidetopharmacology blog 