The drug class of 2014

Around this time of year there is much interest and comment from the pundits concerning the previous year’s drug approvals. Team member Chris Southan has a history of picking out aspects of the PubChem entries on his own blog and has duly done so for 2014  so these are coupled posts that pick out different aspects.  As you might expect,  within the team we follow up on  all drug approval announcements during the year and re-tweet those of particular interest.  Since we have usually already captured the agent as an advanced development candidate, we then update our entry to “approved”. We may also add new links,  such as Phase 3 results, major trade names,  PDB structures and cross-pointers to parent/salt splits between INNs and USANs.

What you can see in the table at the bottom of this post are the 2014 approved drug identifiers, both for the 30 PubChem CIDs and 24 GtoPdb SIDs. There are number of aspects to highlight for our own entries.

1) As explained in FAQ our current capture priorities neither extend to anti-infectives nor to large protein biologicals (other than antibodies).
2) We take diagnostics and imaging probes on a case-by-case basis. In this set we had already curated florbetaben because of its beta amyloid binding data but we have not added the Lumason contrast reagent since it has no reported pharmacology.
3) From the 41 approved drugs, eight of our entries do not have a PubChem CID. This is  either because they are proteins or the peptide has not been submitted as a chemical structure (but our entries specify the amino acid sequence).   However,  these eight do have SIDs (pointing back to us)  because we submit them to PubChem.
4) For the approved antibodies note that our entries uniquely include the quantitative target binding data where we can find this in papers and occasionally patent-only results. It thus complements the sequence records and other information you can find in the IMGT entries that we link to.
5) Note we handle drug mixtures by cross-pointing but in this set they were all anti-infectives and so are not included.
6) With the various exclusions described above we have 17 small-molecule entries for the approved drugs of 2014.
7) Updates for some of these entries will appear in the next database release.

FDA list of New Molecular Entity and New Therapeutic Biological Product Approvals for 2014

o. Drug Trade name INN for parent Date FDA approved indication CID GtoPdb LID GtoPdb SID (if no CID)
1 Farxiga dapaglifozin 01/08/2014 Type 2 diabetes 9887712 4594
2 Hetlioz tasimelteon 1/31/2014 Sleep-wake disorder in blind individuals. 10220503 7393
3 Vimizim elosulfase alfa 2/14/2014 Mucopolysaccharidosis Type IVA (Morquio A syndrome)
4 Northera droxidopa 2/18/2014 Neurogenic orthostatic hypotension (NOH) 92974 7391
5 Myalept metreleptin injection 2/24/2014 Leptin deficiency
6 Neuraceq florbetaben F 18 injection 3/19/2014 Positron Emissionmography (PET) imaging of the brain in Alzheimers 11501341 7769
7 Impavido miltefosine 3/19/2014 Leishmaniasis 3599
8 Otezla apremilast 3/21/2014 Psoriatic arthritis (PsA) 11561674 7372
9 Tanzeum albiglutide 4/15/2014 Type 2 diabetes 7386 178103958
10 Cyramza ramucirumab 4/21/2014 Advanced stomach cancer or gastroesophageal junction adenocarcinoma 7390 178103962
11 Sylvant siltuximab 4/23/2014 Multicentric Castleman’s disease (MCD) lymphoma 7396 178103968
12 Zykadia ceritinib 4/29/2014 Late-stage (metastatic) NSCLC 57379345 7397
13 Zontivity vorapaxar 05/08/2014 Reduce the risk of heart attacks and strokes 10077130 4047
14 Entyvio vedolizumab 5/20/2014 Ulcerative colitis and Crohn‘s disease 7437 178104009
15 Dalvance dalbavancin 5/23/2014 Skin infections 16134410
16 Jublia efinaconazole 06/06/2014 Onychomycosis (fungal infection) 489181
17 Sivextro tedizolid phosphate 6/20/2014 Skin infections 11476460
18 Beleodaq belinostat 07/03/2014 Peripheral T-cell lymphoma (PTCL) 6918638 7496
19 Kerydin tavaborole 07/07/2014 Onychomycosis of the nails 11499245
20 Zydelig idelalisib 7/23/2014 Thee types of blood cancer 11625818 6741
21 Striverdi Respimat olodaterol 7/31/2014 Chronic obstructive pulmonary disease 11504295 7543
22 Jardiance empagliflozin 08/01/2104 Type 2 diabetes 11949646 4754
23 Orbactiv oritavancin 08/06/2014 Skin infections 16136912
24 Belsomra suvorexant 8/13/2014 Insomnia 24965990 2890
25 Plegridy peginterferon beta-1a 8/15/2014 Relapsing multiple sclerosis
26 Cerdelga eliglustat 8/19/2014 Type 1m Gaucher disease 23652731 7536
27 Keytruda pembrolizumab 09/04/2014 Non-responding melanoma 7499 178103956
28 Movantik naloxegol 9/16/2014 Opioid-induced constipation in chronic pain 56959087 7543
29 Trulicity dulaglutide 9/18/2014 Type 2 diabetes. 7638 223365973
30 Harvoni ledipasvir/sofosbuvir 10/10/2014 Hepatitis C virus (HCV) genotype 1 infection 72734365
31 Akynzeo netupitant and palonosetron 10/10/2014 Nausea and vomiting from cancer chemotherapy 78759283
32 Lumason sulfur hexafluoride lipid microsphere 10/10/2014 Impoved contrast for echocardiograms 17358
33 Ofev nintedanib 10/15/2014 Idiopathic pulmonary fibrosis (IPF) 9809715 5936
34 Esbriet pirfenidone 10/15/2014 Idiopathic pulmonary fibrosis (IPF) 40632 7532
35 Blincy blinatumomab 12/03/2014 Philadelphia chromosome-negative B-cell ALL 7384 178103956
36 Xro finafloxacin otic suspension 12/17/2014 Acute otitis externa, (swimmer’s ear) 11567473
37 Lynparza olaparib 12/19/2014 Advanced ovarian cancer 23725625 7519
38 Viekira Pak ombitasvir, paritaprevir and rinavir tablets co-packaged with dasabuvir tablets) 12/19/2014 Chronic hepatitis C virus (HCV) genotype 1 infection, including cirrhosis 86291595
39 Zerbaxa ceflozane/tazobactam 12/19/2014 Complicated intra-abdominal infections (cIAI) and urinary tract infections (cUTI) 86291594
40 Rapivab peramivir 12/19/2014 Influenza 154234
41 Opdivo nivolumab 12/22/2014 Non-responding melanoma 7335 178103907
41 entries 30 CIDs 25 LIDs 8 SIDs
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