The Guide to Pharmacology have been collaborating with AntibioticDB (https://www.antibioticdb.com; ADB) since 2019, with the aim of extending the coverage of antibacterial compounds in GtoPdb and providing comprehensive chemistry and pharmacology for selected antibacterials curated with ADB. The collaboration has been supported more recently by the Global Antibiotic Research and Development Partnership (GARDP; https://gardp.org/).
As part of our work with ADB we support the maintenance and development of their website. This includes recent work that provides 2D structure display with a short-term future aim to provide
structure-based searching and improved filtering capabilities.
We are delighted to draw your attention to a recent publication in ACS Infectious Diseases that provides an overview of the updated AntibioticDB resource, which describes the improvements in content and functionality that have been achieved since the initial description was published in 2018.
Galarion LH, Hennessy A, Harding SD, Armstrong JF, Pentz-Murr A, Davies JA, O’Neill AJ, Piddock LJV. AntibioticDB: An Updated and Improved Open-Access Database for the Antibacterial Research and Development Community. ACS Infect Dis. 2026 Feb 23. doi: 10.1021/acsinfecdis.5c00955. Epub ahead of print. PMID: 41728851
AntibioticDB, originally established in 2017 and led by GARDP since 2021, is a freely available database of antibacterial agents to facilitate research and development of new antibacterial therapeutics. The paper describes the updates and expansions to the resource including new functionalities provided by the web portal. This covers the inclusion of standard chemical identifiers, 2D chemical structure images and associated chemical structure search capabilities.
AntibioticDB now contains over 3,500 individual compound entries, with curation efforts resulting in a significant expansion of historical natural product antibiotics that were previously under-represented in the database. The database is continuously updated by mining the published literature and capturing newly discovered antibacterial compounds as they are reported, making AntibioticDB the most complete global resource on antibacterial agents.
The newly updated web portal is available here: www.antibioticdb.com
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