The latest database version (2014.3) was released on 5th November and includes many content updates and new website enhancements. The current release now covers 7220 distinct ligands interacting at 2708 protein targets (see full statistics on our About page). This post describes all the changes:
- Overview pages for target classes and superfamilies: while browsing the target family lists you can now click on the ‘Overview’ icon to access overviews, subfamily lists and further reading for target super families (Figure 1)
- Search term auto completion: As you type in search terms which match target or ligand names in the database these now come up as a list of suggestions (Figure 2). Clicking on a result links straight to the database page for that entity.
- Searches now work with Greek characters e.g. α,β.
- Removed option to choose whether to go to the concise or detailed view page in target search results. Results link directly to the detailed view if it exists, or to the concise view if it doesn’t.
- Data downloads: new peptide ligand CSV file with sequences and chemical modifications.
Figure 1 – Screenshot of the enzyme family list showing the new overview icon which links to superfamily overview pages.
Figure 2 – Screenshot of search term auto complete suggestions for target and ligand names
- Class Frizzled GPCRs
- Lysophospholipid (LPA) receptors
- Lysophospholipid (S1P) receptors
- Melanin-concentrating hormone receptors
- Melatonin receptors
- Neuropeptide FF/neuropeptide AF receptors
- Adenosine A<sub>2A</sub> receptor
- Complement C5a<sub>1</sub> receptor
- Complement C5a<sub>2</sub> receptor
- Dopamine D<sub>3</sub> receptor
- Inwardly rectifying potassium channels
- Voltage-gated calcium channels
- Selected members of the Two-P potassium channels
- Selected members of the Voltage-gated potassium channels
- Selected members of the Voltage-gated sodium channels
- Kinases: curation of all phase III kinase inhibitors
- Repurposing compounds from NCATS, AstraZeneca Open Innovation and other sources
- AZD compounds
GuidetoPharmacology.org is the new home of IUPHAR-DB
Please note that the original iuphar-db.org site now redirects to guidetopharmacology.org. All target and ligand pages automatically redirect to the corresponding pages on the new site and we are working with other sites that point to us to update their links. Please update your bookmarks and start using the new site. Feel free to send us any comments – we are always looking for ways to improve our site!
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