Database Release August 2015

We’re pleased to announce our second public release of 2015 (version 2015.2) where we have introduced the new features and content updates listed below (and detailed on our download pages) with the objective of becoming more “consumable”.  This is not only an invitation for subsumation into local systems via API calls but also via data downloads.  Please note there are a number of good reasons to contact us early on in the course of any integration efforts, including technical assistance or optimisation where we can, as well as basic professional courtesy for us to know who is using our stuff.  We realise some local instanciations will involve proprietory internal systems (e.g. pharmaceutical companies or competitive intelligence brokers) but we would simply like feedback on how the process (e.g. ETL procedures) went, without needing any disclosure of your internal architecture or content.  We envisage 2015.3 to be ready by about November.

Target updates

Content stats

Interaction type Count
Targets with ligand interactions 1505
Targets with quantitative ligand interactions 1228
Targets with approved drug interactions 554
Primary targets with approved drug interactions 312
Ligands with target interactions 6796
Ligands with quantitative interactions (approved drugs) 5860 (738)
Ligands with clinical use summaries (approved drugs) 1724 (1231)
Number of binding constants 44691
Number of binding constants curated from the literature 13484

Table 1. Interaction counts. Primary target indicates the dominant MMOA.

The table shows a few of the main relationship statistics for the 2015.2 release. Further tables with target and ligand category breakdowns are available on the GtoPdb About page.

Relationship growth since 2012

Figure 1. Relationship growth since 2012.

The first (left-most) chart shows the number of targets with curated ligand interactions while the second chart includes only those targets that are supported by quantitative data. The third and fourth charts show the number of approved drugs with data-supported targets and those that may be considered primary targets, respectively.

Website updates
We have released the first version of our REST web services for beta testing. These provide access to the data in JSON format for integration with other databases and websites. JSON is ideal for reading in with JavaScript and is easier to parse than XML. For further information and the list of web services available please see this page: http://www.guidetopharmacology.org/webServices.jsp. We welcome all feedback, bug reports, and suggestions for further development. Please try them out and let us know how you get on by emailing us. The web services offer access to lists of targets and ligands as well as specific information about targets, ligands and interactions. The web services base URL is http://www.guidetopharmacology.org/services and all target web services can be accessed with the prefix {base_url}/targets while for ligands it is {base_url}/ligands. For example, to download a list of agonists at the target GPER (GtoPdb target Id 221) with pKi >= 7 you would use this URL: http://www.guidetopharmacology.org/services/targets/221/interactions?type=Agonist&affinityType=pKi&affinity=7 For a longer list of examples see the web services documentation page.

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Posted in Database updates, Technical

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