The latest GtoPdb update was released on March 13th and this first release of 2015 includes major updates in several areas.
- Calcitonin receptors; introduction and all receptors
- Dopamine D5 receptor
- Melanocortin receptors introduction
- P2Y1 receptor and P2Y12 receptor
- Parathyroid hormone receptors introduction
- Trace amine TA1 receptor; introduction and receptor page
- Links to BitterDB (database of bitter tasting compounds and their human receptors) added for Taste 2 Receptors
- Data on experimentally generated mutations from GPCRDB. GPCRDB is working with a consortium to collate data on GPCR mutants and is inviting submissions. Thus, the mutation data displayed here will update automatically whenever GPCRDB release new data. (See example for β2-adrenoceptor)
- Added affinity data (where available) for all of the kinase inhibitors in the database (including those we previously only had large-scale matrix screening data for), tagging primary targets where appropriate
- Also added information for kinase inhibitors in clinical trials
Epigenetics target updates
- Added all of the unblinded compounds from SGC’s epigenetics compound repository
- Several new epigenetics targets added into the Other Protein Targets section
- This target class now includes a first (for the database) with a predrug > prodrug > drug triplet. These were curated from a paper describing how MMP12 produces its own inhibitor in a two-step activation procedure. We now have ligand entries for the peptide substrate of the protease, the prodrug and the drug.
- More than 420 new ligands added in this release.
- Many new kinase inhibitors
- New monoclonal antibodies and small molecules included in pharma pipelines (including any novel drug targets)
- Sourced available binding affinity data for all monoclonal antibodies in the database using a combination of BLAST sequence analysis, patent and literature searches, tagging primary targets as appropriate
- More than 20 compounds annotated with new/expanded drug approval information
Disease information updated
- Target pathophysiology sections have been updated with standardised disease nomenclature
- Disease name synonyms added
- More links added to the OMIM and Orphanet disease databases
- Added Disease Ontology nomenclature and links to the Ontobee disease ontology browser
- New “Specialist databases” section created to highlight database links that are of particular interest on specific target and ligand pages, for example the IMGT/mAb-DB resource for antibodies
Ligand search tools
- This version should also be compatible with tablets and mobile devices
- Useful features include the ability to import molecules through various file formats, structural identifiers or by compound name
- Compounds can also be exported in many different formats or as an image file
As always, updated data files are available to download with all the new data.