GtoPdb database release 2015.3

Hot on the heels of the online advance access publication of our Nucleic Acids Research Database Issue 2016 update article we’re pleased to announce our third database release of 2015, 2015.3 published on 19th October.

Here is a summary of the latest updates:

Target updates:

• GPCR updates:
  • Thyrotropin-releasing hormone receptors
  • NOP receptor
• VGIC updates:
  • Members of the Transient Receptor Potential superfamily of channels
• NHR updates:
  • Retinoic acid-related orphans introduction
  • Liver X receptor-α and β
  • COUP-TF-like receptors
  • 3-Ketosteroid receptors
• Enzyme updates:
  • Enzymes involved in hydrogen sulphide synthesis
• New ligand interactions:
  • Quantitative ligand interactions added for about 150 targets which previously had no chemical modulation information in the database. As a consequence our total number of curated interactions now stands at 13859.

Website updates:

• New BLAST tool for sequence-based searching of targets available at http://www.guidetopharmacology.org/blast/.  This bypasses the equivocalities of protein name searching.

View the latest database content stats here.