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Tracey (Altered)2019-04-22T12:35:02+00:00monthlyhttps://blog.guidetopharmacology.org/2019/04/04/hot-topics-rise-up-against-statistical-significance-probably/2019-04-04T10:04:20+00:00monthlyhttps://blog.guidetopharmacology.org/2019/03/28/database-release-2019-2/2019-03-28T12:23:58+00:00monthlyhttps://blog.guidetopharmacology.org/2019/02/26/guide-to-malaria-pharmacology-introducing-a-new-resource/https://blog.guidetopharmacology.org/wp-content/uploads/2019/02/screen-shot-2019-02-25-at-15.02.56.pngScreen Shot 2019-02-25 at 15.02.56https://blog.guidetopharmacology.org/wp-content/uploads/2019/02/screen-shot-2019-02-25-at-14.59.14.pngScreen Shot 2019-02-25 at 14.59.14https://blog.guidetopharmacology.org/wp-content/uploads/2019/02/screen-shot-2019-02-25-at-11.44.39.pngScreen Shot 2019-02-25 at 11.44.39https://blog.guidetopharmacology.org/wp-content/uploads/2019/02/screen-shot-2019-02-25-at-11.42.59.pngScreen Shot 2019-02-25 at 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11.11.59https://blog.guidetopharmacology.org/wp-content/uploads/2019/01/gtommv_banner.jpggtommv_bannerhttps://blog.guidetopharmacology.org/wp-content/uploads/2019/01/gtommv_square_logo.pnggtommv_square_logo2019-02-26T16:01:03+00:00monthlyhttps://blog.guidetopharmacology.org/2019/02/25/hot-topics-exciting-times-for-ion-channel-pharmacology/2019-02-25T15:45:44+00:00monthlyhttps://blog.guidetopharmacology.org/2018/09/19/hot-topic-%ce%b2-subunit-of-the-voltage-gated-ca2-channel-cav1-2-drives-signaling-to-the-nucleus-via-h-ras/2019-02-25T14:38:23+00:00monthlyhttps://blog.guidetopharmacology.org/2018/07/30/hot-topic-direct-activation-of-neuronal-kv7-channels-by-gaba-and-gabapentin-a-novel-mechanism-for-reducing-neuronal-excitability/2019-02-25T14:38:15+00:00monthlyhttps://blog.guidetopharmacology.org/2018/09/19/hot-topic-cryo-em-structure-of-the-active-gs-protein-complexed-human-cgrp-receptor/2019-02-25T14:38:04+00:00monthlyhttps://blog.guidetopharmacology.org/2018/11/02/hot-topic-piezo-channels-and-mechano-transduction-in-sensory-neurons/2019-02-25T14:37:51+00:00monthlyhttps://blog.guidetopharmacology.org/2018/12/05/hot-topic-cellular-thermal-shift-assays-for-target-engagement/2019-02-25T14:37:41+00:00monthlyhttps://blog.guidetopharmacology.org/2018/12/12/hot-topic-somatic-app-gene-recombination-in-normal-and-alzheimers-disease-neurons/2019-02-25T14:37:29+00:00monthlyhttps://blog.guidetopharmacology.org/2018/12/12/hot-topic-gpr37-gpr37l1-and-the-putative-pairing-with-prosaptide-psap/2019-02-25T14:37:23+00:00monthlyhttps://blog.guidetopharmacology.org/2019/02/19/hot-topics-ligand-biological-activity-predicted-by-cleaning-positive-and-negative-chemical-correlations/2019-02-25T14:37:16+00:00monthlyhttps://blog.guidetopharmacology.org/2017/05/15/hot-topics-protein-phospholipid-interplay-revealed-with-crystals-of-a-calcium-pump/2019-02-25T14:37:08+00:00monthlyhttps://blog.guidetopharmacology.org/2019/02/12/hot-topics-an-online-resource-for-gpcr-structure-determination-and-analysis/2019-02-12T16:25:45+00:00monthlyhttps://blog.guidetopharmacology.org/2019/01/30/database-release-2019-1/2019-01-31T15:16:41+00:00monthlyhttps://blog.guidetopharmacology.org/2019/01/15/hot-topics-new-cannabinoid-receptors-structures/2019-01-15T14:40:29+00:00monthlyhttps://blog.guidetopharmacology.org/2019/01/15/gtopdb-at-bps-pharmacology-2018/https://blog.guidetopharmacology.org/wp-content/uploads/2019/01/img_0982.jpgimg_09822019-01-15T09:56:11+00:00monthlyhttps://blog.guidetopharmacology.org/2018/10/26/hot-topics-role-of-rtp-type-d-on-reward-association-with-cocaine-administration/2018-10-26T13:30:21+00:00monthlyhttps://blog.guidetopharmacology.org/2018/09/19/hot-topic-but-in-this-case-stale-beer-the-primary-pharmacological-characterisation-paper-on-bia-10-2747-finally-appears/2018-09-19T18:50:45+00:00monthlyhttps://blog.guidetopharmacology.org/2018/07/31/july-2018-news-updates-and-hot-topics/2018-08-01T13:30:50+00:00monthlyhttps://blog.guidetopharmacology.org/2018/07/24/hot-topic-new-pharmacological-tools-reiterate-lack-of-direct-connection-between-angiotensin-1-7-and-the-mas1-gpcr/2022-02-03T09:36:10+00:00monthlyhttps://blog.guidetopharmacology.org/2018/07/16/hot-topic-structural-detail-of-coupling-of-the-agonist-occupied-%c2%b5-opioid-receptor-amongst-others-to-the-gi-protein/2018-07-23T09:20:28+00:00monthlyhttps://blog.guidetopharmacology.org/2018/07/14/hot-topic-systems-medicine-disease-maps-and-the-future-of-systems-biology/2018-07-17T07:39:51+00:00monthlyhttps://blog.guidetopharmacology.org/2018/06/28/hot-topic-structure-of-the-adenosine-bound-human-adenosine-a1-receptor-gi-complex/2018-06-28T13:50:20+00:00monthlyhttps://blog.guidetopharmacology.org/2018/06/22/commentary-on-the-distinction-between-cannabis-and-cannabinoids/2018-06-22T14:35:51+00:00monthlyhttps://blog.guidetopharmacology.org/2018/05/27/hot-topic-a-double-wammy-for-bace1-inhibitors/2018-06-19T16:32:30+00:00monthlyhttps://blog.guidetopharmacology.org/2018/05/09/database-release-2018-2/https://blog.guidetopharmacology.org/wp-content/uploads/2018/05/tocris_link.pngtocris_linkhttps://blog.guidetopharmacology.org/wp-content/uploads/2018/05/pdb_object_icon.pngPDB_object_iconhttps://blog.guidetopharmacology.org/wp-content/uploads/2018/05/pdb_icon_lig_list.pngPDB_icon_lig_listhttps://blog.guidetopharmacology.org/wp-content/uploads/2018/05/pharm_search_res.pngpharm_search_res2018-06-19T11:01:53+00:00monthlyhttps://blog.guidetopharmacology.org/2018/06/07/gtopdb-database-status-reports/2018-06-07T15:27:06+00:00monthlyhttps://blog.guidetopharmacology.org/2018/05/08/hot-topic-cryo-em-structure-of-the-adenosine-a2a-receptor-coupled-to-an-engineered-heterotrimeric-g-protein/2018-05-08T16:06:01+00:00monthlyhttps://blog.guidetopharmacology.org/2018/05/08/hot-topic-conformational-plasticity-in-the-selectivity-filter-of-the-trpv2-ion-channel/2018-05-08T16:00:26+00:00monthlyhttps://blog.guidetopharmacology.org/2018/05/08/hot-topic-3d-structure-of-the-p2x3-receptor-bound-to-a-negative-allosteric-modifier-identifies-a-binding-site-that-is-a-target-for-development-of-novel-therapeutic-agents/2018-05-08T15:18:24+00:00monthlyhttps://blog.guidetopharmacology.org/2018/03/27/hot-topic-3d-structures-of-the-closed-acid-sensing-ion-channel-asic-shed-light-on-the-activation-mechanism-of-these-neuronal-ion-channels/2018-03-27T11:22:51+00:00monthlyhttps://blog.guidetopharmacology.org/2018/03/21/hot-topic-engineered-mini-g-proteins-provide-a-useful-tool-for-studying-the-activation-of-gpcrs-in-living-cells/2018-03-21T09:42:02+00:00monthlyhttps://blog.guidetopharmacology.org/2018/03/06/gtoimmupdb-technical-update-march-2018-beta-release-v3/https://blog.guidetopharmacology.org/wp-content/uploads/2018/03/portal.pngportalhttps://blog.guidetopharmacology.org/wp-content/uploads/2018/03/proces_assoc_iea.pngproces_assoc_ieahttps://blog.guidetopharmacology.org/wp-content/uploads/2018/03/disease_summary_top.pngdisease_summary_tophttps://blog.guidetopharmacology.org/wp-content/uploads/2018/03/disease_summary_target_ligands.pngdisease_summary_target_ligandshttps://blog.guidetopharmacology.org/wp-content/uploads/2018/03/diseaselist_immuno.pngdiseaselist_immunohttps://blog.guidetopharmacology.org/wp-content/uploads/2018/03/celltype_diagram.pngcelltype_diagramhttps://blog.guidetopharmacology.org/wp-content/uploads/2018/03/adv_search.pngadv_search2018-03-12T10:42:06+00:00monthlyhttps://blog.guidetopharmacology.org/2018/03/09/hot-topic-unexplored-therapeutic-opportunities-in-the-human-genome/2018-04-27T09:53:05+00:00monthlyhttps://blog.guidetopharmacology.org/2018/03/05/database-release-2018-1/https://blog.guidetopharmacology.org/wp-content/uploads/2018/02/disease_list.pngDisease ListThe image shows part of the full disease list. The immunologically-relevant diseases are also shown under a dedicated tab.https://blog.guidetopharmacology.org/wp-content/uploads/2018/02/disease_summary.pngDisease summaryThe top image shows part of the disease list. The bottom image shows a disease summary page with the associated targets and ligands listed.https://blog.guidetopharmacology.org/wp-content/uploads/2018/02/section_of_pharm_search-e1519836338177.pngFigure 2. Pharmacology Search ResultsShowing a section of the results page following a Pharmacology Search. The default search returns the top 5 interactions for each target.2018-03-06T10:21:03+00:00monthlyhttps://blog.guidetopharmacology.org/2018/02/28/hot-topic-the-g-protein-coupled-receptors-deorphanization-landscape/2018-02-28T15:06:08+00:00monthlyhttps://blog.guidetopharmacology.org/2018/01/16/hot-topic-pharmacogenomics-of-gpcr-drug-targets/2018-01-16T12:34:04+00:00monthlyhttps://blog.guidetopharmacology.org/2018/01/10/pubmed-commons-and-altmetrics/2018-01-13T22:40:43+00:00monthlyhttps://blog.guidetopharmacology.org/2017/02/03/reference-citations-in-bjp/https://blog.guidetopharmacology.org/wp-content/uploads/2017/02/capture3.jpgCapturehttps://blog.guidetopharmacology.org/wp-content/uploads/2017/02/capture2.jpgCapturehttps://blog.guidetopharmacology.org/wp-content/uploads/2017/02/capture1.jpgCapturehttps://blog.guidetopharmacology.org/wp-content/uploads/2017/02/capture.jpgCapturehttps://blog.guidetopharmacology.org/wp-content/uploads/2017/02/altmetric.jpgaltmetrichttps://blog.guidetopharmacology.org/wp-content/uploads/2017/02/altmetrics_nars.jpgaltmetrics_narshttps://blog.guidetopharmacology.org/wp-content/uploads/2017/02/pubmed_commons_tweet_feb_2017.jpgpubmed_commons_tweet_feb_2017https://blog.guidetopharmacology.org/wp-content/uploads/2017/02/pubmed_commons_comment_feb_2017.jpgpubmed_commons_comment_feb_2017https://blog.guidetopharmacology.org/wp-content/uploads/2017/02/commons-pointer1.jpgcommons-pointerhttps://blog.guidetopharmacology.org/wp-content/uploads/2017/02/commons-pointer.jpgcommons-pointer2018-01-13T15:36:37+00:00monthlyhttps://blog.guidetopharmacology.org/2017/12/15/impact-statements-and-content-subsumation-bps-2017/2017-12-18T21:55:22+00:00monthlyhttps://blog.guidetopharmacology.org/2017/12/18/hot-topic-trends-in-gpcr-drug-discovery-new-agents-targets-and-indications/2017-12-18T10:30:15+00:00monthlyhttps://blog.guidetopharmacology.org/2017/11/29/database-release-2017-6/https://blog.guidetopharmacology.org/wp-content/uploads/2017/11/immuno_target_search.pngimmuno_target_searchhttps://blog.guidetopharmacology.org/wp-content/uploads/2017/11/cytokine_result.pngcytokine_resulthttps://blog.guidetopharmacology.org/wp-content/uploads/2017/11/searchres-e1511890991662.pngsearchresNew Download as CSV option for search results2017-11-29T12:21:22+00:00monthlyhttps://blog.guidetopharmacology.org/2017/11/29/gtopdb-at-pharmacology-2017/2017-11-29T12:16:34+00:00monthlyhttps://blog.guidetopharmacology.org/2017/11/24/gtoimmupdb-technical-update-november-2017/https://blog.guidetopharmacology.org/wp-content/uploads/2017/11/pathophysiologyautoimmunity_text800.jpgpathophysiologyAutoImmunity_text800https://blog.guidetopharmacology.org/wp-content/uploads/2017/11/nar2018_table1.pngnar2018_table12017-11-24T11:31:16+00:00monthlyhttps://blog.guidetopharmacology.org/2017/11/21/hot-topic-cryo-em-structures-of-mucolipin-trp-channels-in-the-lysosome-five-together-at-once/2023-10-19T01:40:27+00:00monthlyhttps://blog.guidetopharmacology.org/2017/10/30/the-concise-guide-to-pharmacology-201718/https://blog.guidetopharmacology.org/wp-content/uploads/2017/10/310612-bjp-conciseguide-300x150px1.jpg310612-BJP-ConciseGuide-300x150pxhttps://blog.guidetopharmacology.org/wp-content/uploads/2017/10/bjp-conciseguide-signature-400x64px-signature.jpgBJP-ConciseGuide-Signature-400x64px-Signaturehttps://blog.guidetopharmacology.org/wp-content/uploads/2017/10/310612-bjp-conciseguide-1120x604px.jpg310612-BJP-ConciseGuide-1120x604pxhttps://blog.guidetopharmacology.org/wp-content/uploads/2017/10/infographic.pngInfographic2017-10-30T11:54:31+00:00monthlyhttps://blog.guidetopharmacology.org/2016/10/04/synpharm-a-new-annexe-to-the-guide-to-pharmacology/https://blog.guidetopharmacology.org/wp-content/uploads/2016/10/peptide_lig.pngpeptide_ligA peptide ligand (R-spondin-1) bound to its receptor (LGR4), with the bind sequence highlighted in green. See its page for more details.https://blog.guidetopharmacology.org/wp-content/uploads/2016/10/residue_matrix_synpharm.pngresidue_matrix_synpharmA example of a residue distance matrix. The bind sequence is represented by a dotted black line within the context of the protein chain it derives from.2017-10-24T13:54:22+00:00monthlyhttps://blog.guidetopharmacology.org/2017/10/18/gtopdb-nar-database-issue-2018-journal-to-database-connectivity-and-journal-to-gtopdb-links/https://blog.guidetopharmacology.org/wp-content/uploads/2017/10/figure12.pngFigure12https://blog.guidetopharmacology.org/wp-content/uploads/2017/10/figure11.pngFigure112017-10-18T13:33:49+00:00monthlyhttps://blog.guidetopharmacology.org/2017/10/18/gtopdb-nar-database-issue-2018-pubchem-content/https://blog.guidetopharmacology.org/wp-content/uploads/2017/10/figure3.pngFigure3https://blog.guidetopharmacology.org/wp-content/uploads/2017/10/figure4.pngFigure42017-10-18T13:33:31+00:00monthlyhttps://blog.guidetopharmacology.org/2017/09/20/hot-topic-a-new-research-avenue-investigating-mitochondrial-gpcr-biology/2017-09-20T08:24:24+00:00monthlyhttps://blog.guidetopharmacology.org/2017/08/22/new-source-cross-references-in-release-2017-5/2017-09-15T09:55:55+00:00monthlyhttps://blog.guidetopharmacology.org/2017/09/05/crystal-structure-of-lpa6-a-receptor-for-lysophosphatidic-receptor-at-3-2a/2017-09-05T11:07:38+00:00monthlyhttps://blog.guidetopharmacology.org/2017/08/31/hot-topic-fzd6-dimers-dissociate-after-stimulation-briefly/2017-08-31T16:00:27+00:00monthlyhttps://blog.guidetopharmacology.org/2017/08/28/hot-topics-a-cryptic-binding-pocket-in-k2p2-exposes-new-avenues-for-drug-development/2017-08-28T09:23:54+00:00monthlyhttps://blog.guidetopharmacology.org/2017/08/22/database-release-2017-5/https://blog.guidetopharmacology.org/wp-content/uploads/2017/08/stats.pngstatshttps://blog.guidetopharmacology.org/wp-content/uploads/2017/08/db_content.pngdb_content2017-08-24T08:14:53+00:00monthlyhttps://blog.guidetopharmacology.org/2017/08/23/anti-infective-pilot-entries/https://blog.guidetopharmacology.org/wp-content/uploads/2017/08/capture1.jpgCapturehttps://blog.guidetopharmacology.org/wp-content/uploads/2017/08/capture.jpgCapture2017-08-23T13:12:14+00:00monthlyhttps://blog.guidetopharmacology.org/2017/06/19/activity-based-protein-profiling-reveals-off-target-proteins-of-the-faah-inhibitor-bia-10-2474/2017-08-23T10:43:39+00:00monthlyhttps://blog.guidetopharmacology.org/2017/08/22/guide-to-immunopharmacology-beta-release-v2-0-august-2017/https://blog.guidetopharmacology.org/wp-content/uploads/2017/08/process_assoc.pngGtoImmuPdb Process AssociationsRevised layout of process association pages. Navigation items have been moved and new 'return to top' button is present on scroll-downhttps://blog.guidetopharmacology.org/wp-content/uploads/2017/08/helps.pngGtoImmuPdb Help Pop-upsHelp pop-ups added to portalhttps://blog.guidetopharmacology.org/wp-content/uploads/2017/08/further_reading.pngGtoImmuPdb Further ReadingListing papers of relevance to immunopharmacology that are not already used in curated entrieshttps://blog.guidetopharmacology.org/wp-content/uploads/2017/08/disease_assoc.pngDisease Association in GtoImmuPdbAdditional information including if ligands are approved drugs and clinical use comments bring added value2017-08-22T14:50:02+00:00monthlyhttps://blog.guidetopharmacology.org/2017/02/07/gtoimmupdb-technical-update-february-2017/https://blog.guidetopharmacology.org/wp-content/uploads/2017/02/target_to_disease.pngtarget_to_diseasehttps://blog.guidetopharmacology.org/wp-content/uploads/2017/02/portal_v3.pngportal_v3https://blog.guidetopharmacology.org/wp-content/uploads/2017/02/ligand_summary_immu_tab.pngligand_summary_immu_tab2017-07-31T14:23:18+00:00monthlyhttps://blog.guidetopharmacology.org/2017/07/13/hot-topic-identifiers-for-the-21st-century/2017-07-14T09:02:09+00:00monthlyhttps://blog.guidetopharmacology.org/2017/06/30/hot-topic-x-ray-crystal-of-the-apelin-receptor/2017-07-13T13:10:51+00:00monthlyhttps://blog.guidetopharmacology.org/2017/07/13/hot-topics-agonist-bound-crystal-structures-of-the-cb1-cannabinoid-receptor/2017-07-13T13:10:30+00:00monthlyhttps://blog.guidetopharmacology.org/2017/06/20/hgnc-gene-links-to-gtopdb/https://blog.guidetopharmacology.org/wp-content/uploads/2017/06/genes.pnggenesFigure 5. Part of the CSV file containing all the HGNC links to GtoPdb showing some of the new ligand 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guide to IMMUNOPHARMACOLOGy poster, presented at Pharmacology 2016https://blog.guidetopharmacology.org/wp-content/uploads/2016/12/flash_poster_image.pngflash_poster_imageThe IUPHAR Guide to IMMUNOPHARMACOLOGY flash 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growth since 2012.The first (left-most) chart shows the number of targets with curated ligand interactions while the second chart includes only those targets that are supported by quantitative data. 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