Hot topics: Social network architecture of human immune cells unveiled by quantitative proteomics

The authors applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. The protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. They discuss the fundamental intercellular communication structures and previously unknown connections between cell types. The publicly accessible (http://www.immprot.org/) proteomic resource provides a framework for the orchestration of cellular interplay and a reference for altered communication associated with pathology.

[1] Rieckmann et al. (2017). Nat. Immunol. doi: 10.1038/ni.3693. [Epub ahead of print]. Social network architecture of human immune cells unveiled by quantitative proteomics. [PMID 28263321].

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