Hot topics: Ligand and Target Discovery by Fragment-Based Screening in Human Cells

Description of a platform that marries fragment-based ligand discovery with quantitative chemical proteomics to map thousands of reversible small molecule-protein interactions directly in human cells, many of which can be site-specifically determined.

[1] Parker et al. (2017).Cell. 168(3):527-541. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. [Cell article]

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