Sepsis is a systemic inflammatory response to infection, accounting for the most common cause of death in intensive care units. Here, we report that peripheral administration of the hypothalamic neuropeptide orexin improves the survival of mice with lipopolysaccharide (LPS) induced endotoxin shock, a well-studied septic shock model.
oxerin-A (GtoPdb ligand ID: 1697)
oxerin-B (GtoPdb ligand ID: 1699)
 Ogawa et al. (2017). Elife 5:e21055. Peripherally administered orexin improves survival of mice with endotoxin shock. [PMID: 28035899]
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