Hot topics: Peripherally administered orexin improves survival of mice with endotoxin shock

Sepsis is a systemic inflammatory response to infection, accounting for the most common cause of death in intensive care units. Here, we report that peripheral administration of the hypothalamic neuropeptide orexin improves the survival of mice with lipopolysaccharide (LPS) induced endotoxin shock, a well-studied septic shock model.

oxerin-A (GtoPdb ligand ID: 1697)

oxerin-B (GtoPdb ligand ID: 1699)

[1] Ogawa et al. (2017). Elife 5:e21055. Peripherally administered orexin improves survival of mice with endotoxin shock. [PMID: 28035899]

Comments by Curation Team

Advertisements
Posted in Hot Topics

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: