Hot topics: Structures of the Human HCN1 Hyperpolarization-Activated Channel

Presenting cryo-electron microscopy structures of the human HCN channel in the absence and presence of cAMP at 3.5 Å resolution. HCN channels contain a K+channel selectivity filter-forming sequence from which the amino acids create a unique structure that explains Na+ and K+ permeability. These structures advance understanding of ion selectivity, reversed polarity gating, and cAMP regulation in HCN channels

[1] Lee C.H. & MacKinnon R. (2017). Cell 168(1-2):111-120. Structures of the Human HCN1 Hyperpolarization-Activated Channel. [PMID: 28086084].

Comments by Curation Team

Advertisements
Posted in Hot Topics

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: