Presenting cryo-electron microscopy structures of the human HCN channel in the absence and presence of cAMP at 3.5 Å resolution. HCN channels contain a K+channel selectivity filter-forming sequence from which the amino acids create a unique structure that explains Na+ and K+ permeability. These structures advance understanding of ion selectivity, reversed polarity gating, and cAMP regulation in HCN channels
 Lee C.H. & MacKinnon R. (2017). Cell 168(1-2):111-120. Structures of the Human HCN1 Hyperpolarization-Activated Channel. [PMID: 28086084].
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