Hot topics: Crystal Structure of an LSD-Bound Human Serotonin Receptor

The prototypical hallucinogen LSD acts via serotonin receptors, and here we describe the crystal structure of LSD in complex with the human serotonin receptor 5-HT2B. This study thus reveals an unexpected binding mode of LSD; illuminates key features of its kinetics, stereochemistry, and signaling; and provides a molecular explanation for LSD’s actions at human serotonin receptors.

[1] Wacker et al. (2017). Cell 168(3):377-389. Crystal Structure of an LSD-Bound Human Serotonin Receptor. [PMID: 28129538]

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