Hot topics: Visualizing GPCR ‘Megaplexes’ Which Enable Sustained Intracellular Signaling

Spotlight article [1] discussing the range of cutting-edge techniques that have been employed to visualize ‘megaplexes’ consisting of a G protein-coupled receptor (GPCR) bound to β-arrestin in intracellular endosomes following agonist-induced internalization. Surprisingly, the complex includes simultaneous binding of the heterotrimeric G protein, which retains full functional activity and supports sustained signaling from within the cell.

[1] Marshall F.H. (2016). Trends Biochem Sci. 41(12):985-986. Visualizing GPCR ‘Megaplexes’ Which Enable Sustained Intracellular Signaling. [PMID: 27825513]

Comments by Curation Team

Advertisements
Posted in Hot Topics

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: