Hot topics: Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

A report on the structures of type 2 ryanodine receptor from porcine heart at near-atomic resolution [1]. Structural and mutational characterisations provide important insights into the gating and disease mechanisms of RyR2.

Guide to Pharmacology: Ryanodine receptor family.

[1] Peng et al. (2016). Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science. 354 (6310). [PMID: 27708056]

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